Diltiazem EP Impurity A HCl CAS 111188-71-7(free base)
| CAS No. | 111188-71-7(free base) |
| Molecular Formula | C22H26N2O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Diltiazem EP Impurity A HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base)), a pharmacopoeial impurity reference standard (molecular formula C22H26N2O4SHCl, MW 450.98 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Diltiazem EP Impurity A HCl is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 450.98 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H26N2O4S HCl |
| Molecular Weight | 450.98 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 103532-27-0)
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
- L-Diltiazem (CAS 1217650-51-5)
Recommended Standards
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- tert-Butyl 3-bromo-1-methyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate (CAS 1393539-88-2)
- 5-Cyclopropoxy-3-methoxypicolinic acid (CAS 1243464-55-2)
- 5-(2,3-Dimethylphenyl)pyrimidin-2-ol (CAS 1111108-60-1)
- 4-Butylpyrimidine (CAS 28918-79-8)
- Methyl 4-(4-hydroxypiperidin-4-yl)benzoate hydrochloride (CAS 2444880-53-7)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com